With age, all humans experience a decline in immune system health, which contributes to degenerative conditions within the body, including muscle atrophy. Age-related muscle atrophy (sarcopenia) and muscle wasting from disuse or disease significantly compromises quality of life by causing impaired mobility. Dr. Keirstead was awarded the opportunity to speak on the main stage of the RSS event to describe Immunis’ use of a unique stem cell secretome to combat age and disease-related immune decline. In his speech, Dr. Keirstead will discuss Immunis’ FDA-approved Phase 1/2a clinical trial for the use of IMM01-STEM in patients with muscle atrophy associated with knee osteoarthritis, a condition which combines disuse, age and disease-related muscle atrophy.
About Rejuvenation Startup Summit
As longevity biotechnology is considered a new, emerging field of medicine, this networking event aims to optimize development of the rejuvenation biotech industry. For additional information about the Rejuvenation Startup Summit please visit: www.forever-healthy.org/summit/
About Immunis Inc.
Immunis is a private biotechnology company developing a novel immunomodulatory secretome product for the various manifestations of age and disease-related immune decline. The STEM product line leverages Immunis’ leading-edge capabilities in stem cell technologies to deliver a product of all natural, all human immune modulators in their natural relative physiological concentrations. For additional information about Immunis’ IMM01-STEM Phase 1/2a trial please visit: www.immunisbiomedical.com
Immunis’ FDA-awarded Phase 1/2a clinical trial is an open-label dose escalation study to assess the safety and tolerability of IMM01-STEM in elderly participants with muscle atrophy associated with knee osteoarthritis. Up to 18 patients will be enrolled in the trial and randomly assigned to an IMM01-STEM dose cohort. Treatment will be administered in the form of intramuscular injections twice a week for four weeks (8 injections total). Male or female patients are eligible for the study if they satisfy the following criteria: (1) 50 to 75 years of age at the time of signing the informed consent, (2) have a grade 2 or 3 knee osteoarthritis as defined by Kellgren-Lawrence analyses, (3) have quadricep weakness (<7.5N/kg/m2), (4) can ambulate >50 feet unassisted, (5) are negative for human immunodeficiency virus, hepatitis B surface antigen (HBsAg), and hepatitis C at the Screening Visit and (6) have a body mass index (BMI) of <40kg/m2. For additional information about Immunis’ trial participant qualifications, please visit: www.immunisbiomedical.com
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