Cell-Derived Secretomes for Immune Modulation

Secretomes in support of immune health

Immunis has developed a novel method to grow human cells for clinical use and direct them to become highly pure populations of defined cells that secrete factors which benefit immune system development, modulation, and health. With age, everyone experiences a reduction in these valuable factors; and our technology replaces them. Our investigational secretome product (IMMUNA) is all natural, all human, and represents a perfectly balanced set of immune modulators in naturally occurring, relevant physiological concentrations.

IMMUNA Formulation

Immunis' investigational IMMUNA secretome is a non-cell-based secretome product derived from partially differentiated human cells and is composed of a multitude of pro-regenerative factors involved in immunomodulation, cytoskeleton remodeling, and growth factor-mediated cellular signaling. It is a sterile and nonpyrogenic aqueous solution manufactured under cGMP conditions. IMMUNA does not contain live cells or any cell fragments. It is all natural, all human, and contains a multitude of factors known to benefit immune system development and health.

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Changing the course of immune-related disease and ageing.

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Immune
Progenitors

Immune progenitors are a type of stem cell that support immune function.

Their secretions — or secretome — regulate cell survival, renewal, inflammation and other functions critical to immune health.

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Age and disease-related
Immune Decline

As we age, progenitor cell activity decreases and their secreted factors are fewer. Disease can also lead to deficits in immune function.

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IMMUNA

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introducing

Secretomes for age and disease-related immune decline.

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The Secretome Advantage

IMMUNA is all natural, all human, and represents a perfectly balanced set of immune modulators in naturally occurring relevant physiological concentrations

...restoring critical immune components lost with age.

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Potential

Applications

In preclinical studies, IMMUNA was found to improve muscular atrophy, metabolic & vascular function, tissue inflammation, immune cell function, and exosome/extracellular vesicle composition. These findings reveal potential uses for IMMUNA in the treatment of several age and immune-associated disease indications.

IMMUNA increases muscle fiber density (red; before=left; after=right)

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Pre-Clinical Safety and Efficacy Studies

Third-party preclinical safety studies confirmed the product to be safe and well tolerated.

Preclinical data supports that IMMUNA enhances metabolism and muscle regeneration. IMMUNA has also been shown to benefit vascular function, tissue inflammation, immune cell function, and exosome/extracellular vesicle composition in several age and immune-associated disease indications.

Pre-clinical studies of our investigational secretome product show a decrease in arterial stiffness with age.

Publications

Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells

Dennis K Fix, Ziad S Mahmassani, Jonathan J Petrocelli, Naomi M M P de Hart, Patrick J Ferrara, Jessie S Painter, Gabriel Nistor, Thomas E Lane, Hans S Keirstead, Micah J Drummond

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